Ledipasvir and sofosbuvir plus ribavirin in patients with genotype 1 or 4 hepatitis C virus infection and advanced liver disease: a multicentre, open-label, randomised, phase 2 trial.
Identifieur interne : 001B98 ( Main/Exploration ); précédent : 001B97; suivant : 001B99Ledipasvir and sofosbuvir plus ribavirin in patients with genotype 1 or 4 hepatitis C virus infection and advanced liver disease: a multicentre, open-label, randomised, phase 2 trial.
Auteurs : Michael Manns [Allemagne] ; Didier Samuel [France] ; Edward J. Gane [Nouvelle-Zélande] ; David Mutimer [Royaume-Uni] ; Geoff Mccaughan [Australie] ; Maria Buti [Espagne] ; Martín Prieto [Espagne] ; José Luis Calleja [Espagne] ; Markus Peck-Radosavljevic [Autriche] ; Beat Müllhaupt [Suisse] ; Kosh Agarwal [Royaume-Uni] ; Peter Angus [Australie] ; Eric M. Yoshida [Canada] ; Massimo Colombo [Italie] ; Mario Rizzetto [Italie] ; Hadas Dvory-Sobol [États-Unis] ; Jill Denning [États-Unis] ; Sarah Arterburn [États-Unis] ; Phillip S. Pang [États-Unis] ; Diana Brainard [États-Unis] ; John G. Mchutchison [États-Unis] ; Jean-François Dufour [Suisse] ; Hans Van Vlierberghe [Belgique] ; Bart Van Hoek [Pays-Bas] ; Xavier Forns [Espagne]Source :
- The Lancet. Infectious diseases [ 1474-4457 ] ; 2016.
Descripteurs français
- KwdFr :
- ARN viral, Adulte d'âge moyen, Antiviraux (usage thérapeutique), Association de médicaments, Benzimidazoles (usage thérapeutique), Charge virale, Cirrhose du foie (mortalité), Cirrhose du foie (traitement médicamenteux), Cirrhose du foie (virologie), Facteurs temps, Femelle, Fluorènes (usage thérapeutique), Génotype, Hepacivirus (), Hepacivirus (génétique), Humains, Hépatite C chronique (), Hépatite C chronique (mortalité), Hépatite C chronique (traitement médicamenteux), Mâle, Ribavirine (usage thérapeutique), Résultat thérapeutique, Santé mondiale, Uridine monophosphate (analogues et dérivés), Uridine monophosphate (usage thérapeutique).
- MESH :
- analogues et dérivés : Uridine monophosphate.
- génétique : Hepacivirus.
- mortalité : Cirrhose du foie, Hépatite C chronique.
- traitement médicamenteux : Cirrhose du foie, Hépatite C chronique.
- usage thérapeutique : Antiviraux, Benzimidazoles, Fluorènes, Ribavirine, Uridine monophosphate.
- virologie : Cirrhose du foie.
- ARN viral, Adulte d'âge moyen, Association de médicaments, Charge virale, Facteurs temps, Femelle, Génotype, Hepacivirus, Humains, Hépatite C chronique, Mâle, Résultat thérapeutique, Santé mondiale.
English descriptors
- KwdEn :
- Antiviral Agents (therapeutic use), Benzimidazoles (therapeutic use), Drug Therapy, Combination, Female, Fluorenes (therapeutic use), Genotype, Global Health, Hepacivirus (classification), Hepacivirus (drug effects), Hepacivirus (genetics), Hepatitis C, Chronic (complications), Hepatitis C, Chronic (drug therapy), Hepatitis C, Chronic (mortality), Humans, Liver Cirrhosis (drug therapy), Liver Cirrhosis (mortality), Liver Cirrhosis (virology), Male, Middle Aged, RNA, Viral, Ribavirin (therapeutic use), Time Factors, Treatment Outcome, Uridine Monophosphate (analogs & derivatives), Uridine Monophosphate (therapeutic use), Viral Load.
- MESH :
- chemical , analogs & derivatives : Uridine Monophosphate.
- chemical , therapeutic use : Antiviral Agents, Benzimidazoles, Fluorenes, Ribavirin, Uridine Monophosphate.
- classification : Hepacivirus.
- complications : Hepatitis C, Chronic.
- drug effects : Hepacivirus.
- drug therapy : Hepatitis C, Chronic, Liver Cirrhosis.
- genetics : Hepacivirus.
- mortality : Hepatitis C, Chronic, Liver Cirrhosis.
- virology : Liver Cirrhosis.
- Drug Therapy, Combination, Female, Genotype, Global Health, Humans, Male, Middle Aged, RNA, Viral, Time Factors, Treatment Outcome, Viral Load.
Abstract
Treatment options are limited for patients infected by hepatitis C virus (HCV) with advanced liver disease. We assessed the safety and efficacy of ledipasvir, sofosbuvir, and ribavirin in patients with HCV genotype 1 or 4 and advanced liver disease.
DOI: 10.1016/S1473-3099(16)00052-9
PubMed: 26907736
Affiliations:
- Allemagne, Australie, Autriche, Belgique, Canada, Espagne, France, Italie, Nouvelle-Zélande, Pays-Bas, Royaume-Uni, Suisse, États-Unis
- Angleterre, Californie, Canton de Berne, Canton de Zurich, Catalogne, Communauté de Madrid, Grand Londres, Hollande-Méridionale, Lombardie, Midlands de l'Ouest, Nouvelle-Galles du Sud, Piémont, Vienne (Autriche)
- Barcelone, Berne, Birmingham, Leyde, Londres, Madrid, Milan, Sydney, Turin, Vienne (Autriche), Zurich
- Université de Berne, Université de Sydney
Links toward previous steps (curation, corpus...)
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Le document en format XML
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Gane</name><affiliation wicri:level="1"><nlm:affiliation>New Zealand Liver Transplant Unit, Auckland City Hospital, Auckland, New Zealand.</nlm:affiliation><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>New Zealand Liver Transplant Unit, Auckland City Hospital, Auckland</wicri:regionArea><wicri:noRegion>Auckland</wicri:noRegion></affiliation></author><author><name sortKey="Mutimer, David" sort="Mutimer, David" uniqKey="Mutimer D" first="David" last="Mutimer">David Mutimer</name><affiliation wicri:level="3"><nlm:affiliation>Queen Elizabeth Hospital and NIHR Liver Biomedical Research Unit, Birmingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Queen Elizabeth Hospital and NIHR Liver Biomedical Research Unit, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName></affiliation></author><author><name sortKey="Mccaughan, Geoff" sort="Mccaughan, Geoff" uniqKey="Mccaughan G" first="Geoff" last="Mccaughan">Geoff Mccaughan</name><affiliation wicri:level="4"><nlm:affiliation>Australian Liver Transplant Unit, Centenary Research Institute, Royal Prince Alfred Hospital, University of Sydney, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Liver Transplant Unit, Centenary Research Institute, Royal Prince Alfred Hospital, University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Buti, Maria" sort="Buti, Maria" uniqKey="Buti M" first="Maria" last="Buti">Maria Buti</name><affiliation wicri:level="3"><nlm:affiliation>Internal Medicine and Hepatology, CIBERHED Vall d'Hebron University Hospital, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Internal Medicine and Hepatology, CIBERHED Vall d'Hebron University Hospital, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Prieto, Martin" sort="Prieto, Martin" uniqKey="Prieto M" first="Martín" last="Prieto">Martín Prieto</name><affiliation wicri:level="1"><nlm:affiliation>Digestive Diseases Service, Hospital Universitario y Politécnico La Fe, and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Valencia, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Digestive Diseases Service, Hospital Universitario y Politécnico La Fe, and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation></author><author><name sortKey="Calleja, Jose Luis" sort="Calleja, Jose Luis" uniqKey="Calleja J" first="José Luis" last="Calleja">José Luis Calleja</name><affiliation wicri:level="3"><nlm:affiliation>Servicio de Gastroenterología y Hepatología Hospital Universitario Puerta de Hierro Universidad Autonoma, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Servicio de Gastroenterología y Hepatología Hospital Universitario Puerta de Hierro Universidad Autonoma, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Peck Radosavljevic, Markus" sort="Peck Radosavljevic, Markus" uniqKey="Peck Radosavljevic M" first="Markus" last="Peck-Radosavljevic">Markus Peck-Radosavljevic</name><affiliation wicri:level="3"><nlm:affiliation>Department of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Gastroenterology and Hepatology, Medical University of Vienna, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Mullhaupt, Beat" sort="Mullhaupt, Beat" uniqKey="Mullhaupt B" first="Beat" last="Müllhaupt">Beat Müllhaupt</name><affiliation wicri:level="3"><nlm:affiliation>Department for Gastroenterology and Hepatology UniversitätsSpital Zürich, Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department for Gastroenterology and Hepatology UniversitätsSpital Zürich, Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Agarwal, Kosh" sort="Agarwal, Kosh" uniqKey="Agarwal K" first="Kosh" last="Agarwal">Kosh Agarwal</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Liver Studies, King's College Hospital Foundation Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Liver Studies, King's College Hospital Foundation Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Angus, Peter" sort="Angus, Peter" uniqKey="Angus P" first="Peter" last="Angus">Peter Angus</name><affiliation wicri:level="1"><nlm:affiliation>Liver Transplant Unit, Austin Hospital, Heidelberg, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Liver Transplant Unit, Austin Hospital, Heidelberg, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Yoshida, Eric M" sort="Yoshida, Eric M" uniqKey="Yoshida E" first="Eric M" last="Yoshida">Eric M. Yoshida</name><affiliation wicri:level="1"><nlm:affiliation>Division of Gastroenterology, Vancouver General Hospital and University of British Columbia, Vancouver, BC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Gastroenterology, Vancouver General Hospital and University of British Columbia, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Colombo, Massimo" sort="Colombo, Massimo" uniqKey="Colombo M" first="Massimo" last="Colombo">Massimo Colombo</name><affiliation wicri:level="3"><nlm:affiliation>Department of Gastroenterology, IRCCS Maggiore Hospital University of Milan, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Gastroenterology, IRCCS Maggiore Hospital University of Milan, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Rizzetto, Mario" sort="Rizzetto, Mario" uniqKey="Rizzetto M" first="Mario" last="Rizzetto">Mario Rizzetto</name><affiliation wicri:level="3"><nlm:affiliation>Azienda Ospedaliero-Universitaria, Torino, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Azienda Ospedaliero-Universitaria, Torino</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Dvory Sobol, Hadas" sort="Dvory Sobol, Hadas" uniqKey="Dvory Sobol H" first="Hadas" last="Dvory-Sobol">Hadas Dvory-Sobol</name><affiliation wicri:level="2"><nlm:affiliation>Gilead Sciences, Foster City, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gilead Sciences, Foster City, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Denning, Jill" sort="Denning, Jill" uniqKey="Denning J" first="Jill" last="Denning">Jill Denning</name><affiliation wicri:level="2"><nlm:affiliation>Gilead Sciences, Foster City, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gilead Sciences, Foster City, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Arterburn, Sarah" sort="Arterburn, Sarah" uniqKey="Arterburn S" first="Sarah" last="Arterburn">Sarah Arterburn</name><affiliation wicri:level="2"><nlm:affiliation>Gilead Sciences, Foster City, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gilead Sciences, Foster City, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Pang, Phillip S" sort="Pang, Phillip S" uniqKey="Pang P" first="Phillip S" last="Pang">Phillip S. Pang</name><affiliation wicri:level="2"><nlm:affiliation>Gilead Sciences, Foster City, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gilead Sciences, Foster City, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Brainard, Diana" sort="Brainard, Diana" uniqKey="Brainard D" first="Diana" last="Brainard">Diana Brainard</name><affiliation wicri:level="2"><nlm:affiliation>Gilead Sciences, Foster City, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gilead Sciences, Foster City, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Mchutchison, John G" sort="Mchutchison, John G" uniqKey="Mchutchison J" first="John G" last="Mchutchison">John G. Mchutchison</name><affiliation wicri:level="2"><nlm:affiliation>Gilead Sciences, Foster City, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gilead Sciences, Foster City, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Dufour, Jean Francois" sort="Dufour, Jean Francois" uniqKey="Dufour J" first="Jean-François" last="Dufour">Jean-François Dufour</name><affiliation wicri:level="4"><nlm:affiliation>Department of Hepatology, University of Bern, Bern, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Hepatology, University of Bern, Bern</wicri:regionArea><placeName><settlement type="city">Berne</settlement><region type="région" nuts="3">Canton de Berne</region><settlement type="city">Berne</settlement></placeName><orgName type="university">Université de Berne</orgName></affiliation></author><author><name sortKey="Van Vlierberghe, Hans" sort="Van Vlierberghe, Hans" uniqKey="Van Vlierberghe H" first="Hans" last="Van Vlierberghe">Hans Van Vlierberghe</name><affiliation wicri:level="1"><nlm:affiliation>Ghent University Hospital, Ghent, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Ghent University Hospital, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Van Hoek, Bart" sort="Van Hoek, Bart" uniqKey="Van Hoek B" first="Bart" last="Van Hoek">Bart Van Hoek</name><affiliation wicri:level="3"><nlm:affiliation>Department of Gastroenterology and Hepatology, Leiden University Medical Centre, Leiden, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Gastroenterology and Hepatology, Leiden University Medical Centre, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Forns, Xavier" sort="Forns, Xavier" uniqKey="Forns X" first="Xavier" last="Forns">Xavier Forns</name><affiliation wicri:level="3"><nlm:affiliation>Liver Unit, Hospital Clinic, CIBEREHD, IDIBAPS, University of Barcelona, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Liver Unit, Hospital Clinic, CIBEREHD, IDIBAPS, University of Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26907736</idno><idno type="pmid">26907736</idno><idno type="doi">10.1016/S1473-3099(16)00052-9</idno><idno type="wicri:Area/PubMed/Corpus">001E20</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001E20</idno><idno type="wicri:Area/PubMed/Curation">001D96</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001D96</idno><idno type="wicri:Area/PubMed/Checkpoint">001D96</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001D96</idno><idno type="wicri:Area/Ncbi/Merge">003174</idno><idno type="wicri:Area/Ncbi/Curation">003174</idno><idno type="wicri:Area/Ncbi/Checkpoint">003174</idno><idno type="wicri:Area/Main/Merge">001B95</idno><idno type="wicri:Area/Main/Curation">001B98</idno><idno type="wicri:Area/Main/Exploration">001B98</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Ledipasvir and sofosbuvir plus ribavirin in patients with genotype 1 or 4 hepatitis C virus infection and advanced liver disease: a multicentre, open-label, randomised, phase 2 trial.</title><author><name sortKey="Manns, Michael" sort="Manns, Michael" uniqKey="Manns M" first="Michael" last="Manns">Michael Manns</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany; German Center of Infection Research (DZIF), Hannover-Braunschweig, Germany. Electronic address: manns.michael@mh-hannover.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany; German Center of Infection Research (DZIF), Hannover-Braunschweig</wicri:regionArea><wicri:noRegion>Hannover-Braunschweig</wicri:noRegion><wicri:noRegion>Hannover-Braunschweig</wicri:noRegion><wicri:noRegion>Hannover-Braunschweig</wicri:noRegion></affiliation></author><author><name sortKey="Samuel, Didier" sort="Samuel, Didier" uniqKey="Samuel D" first="Didier" last="Samuel">Didier Samuel</name><affiliation wicri:level="1"><nlm:affiliation>Centre Hepatobiliaire, Hôpital Paul Brousse, and Université Paris Sud, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre Hepatobiliaire, Hôpital Paul Brousse, and Université Paris Sud, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Gane, Edward J" sort="Gane, Edward J" uniqKey="Gane E" first="Edward J" last="Gane">Edward J. Gane</name><affiliation wicri:level="1"><nlm:affiliation>New Zealand Liver Transplant Unit, Auckland City Hospital, Auckland, New Zealand.</nlm:affiliation><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>New Zealand Liver Transplant Unit, Auckland City Hospital, Auckland</wicri:regionArea><wicri:noRegion>Auckland</wicri:noRegion></affiliation></author><author><name sortKey="Mutimer, David" sort="Mutimer, David" uniqKey="Mutimer D" first="David" last="Mutimer">David Mutimer</name><affiliation wicri:level="3"><nlm:affiliation>Queen Elizabeth Hospital and NIHR Liver Biomedical Research Unit, Birmingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Queen Elizabeth Hospital and NIHR Liver Biomedical Research Unit, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName></affiliation></author><author><name sortKey="Mccaughan, Geoff" sort="Mccaughan, Geoff" uniqKey="Mccaughan G" first="Geoff" last="Mccaughan">Geoff Mccaughan</name><affiliation wicri:level="4"><nlm:affiliation>Australian Liver Transplant Unit, Centenary Research Institute, Royal Prince Alfred Hospital, University of Sydney, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Liver Transplant Unit, Centenary Research Institute, Royal Prince Alfred Hospital, University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Buti, Maria" sort="Buti, Maria" uniqKey="Buti M" first="Maria" last="Buti">Maria Buti</name><affiliation wicri:level="3"><nlm:affiliation>Internal Medicine and Hepatology, CIBERHED Vall d'Hebron University Hospital, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Internal Medicine and Hepatology, CIBERHED Vall d'Hebron University Hospital, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Prieto, Martin" sort="Prieto, Martin" uniqKey="Prieto M" first="Martín" last="Prieto">Martín Prieto</name><affiliation wicri:level="1"><nlm:affiliation>Digestive Diseases Service, Hospital Universitario y Politécnico La Fe, and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Valencia, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Digestive Diseases Service, Hospital Universitario y Politécnico La Fe, and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation></author><author><name sortKey="Calleja, Jose Luis" sort="Calleja, Jose Luis" uniqKey="Calleja J" first="José Luis" last="Calleja">José Luis Calleja</name><affiliation wicri:level="3"><nlm:affiliation>Servicio de Gastroenterología y Hepatología Hospital Universitario Puerta de Hierro Universidad Autonoma, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Servicio de Gastroenterología y Hepatología Hospital Universitario Puerta de Hierro Universidad Autonoma, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Peck Radosavljevic, Markus" sort="Peck Radosavljevic, Markus" uniqKey="Peck Radosavljevic M" first="Markus" last="Peck-Radosavljevic">Markus Peck-Radosavljevic</name><affiliation wicri:level="3"><nlm:affiliation>Department of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Gastroenterology and Hepatology, Medical University of Vienna, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Mullhaupt, Beat" sort="Mullhaupt, Beat" uniqKey="Mullhaupt B" first="Beat" last="Müllhaupt">Beat Müllhaupt</name><affiliation wicri:level="3"><nlm:affiliation>Department for Gastroenterology and Hepatology UniversitätsSpital Zürich, Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department for Gastroenterology and Hepatology UniversitätsSpital Zürich, Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Agarwal, Kosh" sort="Agarwal, Kosh" uniqKey="Agarwal K" first="Kosh" last="Agarwal">Kosh Agarwal</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Liver Studies, King's College Hospital Foundation Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Liver Studies, King's College Hospital Foundation Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Angus, Peter" sort="Angus, Peter" uniqKey="Angus P" first="Peter" last="Angus">Peter Angus</name><affiliation wicri:level="1"><nlm:affiliation>Liver Transplant Unit, Austin Hospital, Heidelberg, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Liver Transplant Unit, Austin Hospital, Heidelberg, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Yoshida, Eric M" sort="Yoshida, Eric M" uniqKey="Yoshida E" first="Eric M" last="Yoshida">Eric M. Yoshida</name><affiliation wicri:level="1"><nlm:affiliation>Division of Gastroenterology, Vancouver General Hospital and University of British Columbia, Vancouver, BC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Gastroenterology, Vancouver General Hospital and University of British Columbia, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Colombo, Massimo" sort="Colombo, Massimo" uniqKey="Colombo M" first="Massimo" last="Colombo">Massimo Colombo</name><affiliation wicri:level="3"><nlm:affiliation>Department of Gastroenterology, IRCCS Maggiore Hospital University of Milan, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Gastroenterology, IRCCS Maggiore Hospital University of Milan, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Rizzetto, Mario" sort="Rizzetto, Mario" uniqKey="Rizzetto M" first="Mario" last="Rizzetto">Mario Rizzetto</name><affiliation wicri:level="3"><nlm:affiliation>Azienda Ospedaliero-Universitaria, Torino, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Azienda Ospedaliero-Universitaria, Torino</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Dvory Sobol, Hadas" sort="Dvory Sobol, Hadas" uniqKey="Dvory Sobol H" first="Hadas" last="Dvory-Sobol">Hadas Dvory-Sobol</name><affiliation wicri:level="2"><nlm:affiliation>Gilead Sciences, Foster City, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gilead Sciences, Foster City, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Denning, Jill" sort="Denning, Jill" uniqKey="Denning J" first="Jill" last="Denning">Jill Denning</name><affiliation wicri:level="2"><nlm:affiliation>Gilead Sciences, Foster City, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gilead Sciences, Foster City, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Arterburn, Sarah" sort="Arterburn, Sarah" uniqKey="Arterburn S" first="Sarah" last="Arterburn">Sarah Arterburn</name><affiliation wicri:level="2"><nlm:affiliation>Gilead Sciences, Foster City, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gilead Sciences, Foster City, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Pang, Phillip S" sort="Pang, Phillip S" uniqKey="Pang P" first="Phillip S" last="Pang">Phillip S. Pang</name><affiliation wicri:level="2"><nlm:affiliation>Gilead Sciences, Foster City, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gilead Sciences, Foster City, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Brainard, Diana" sort="Brainard, Diana" uniqKey="Brainard D" first="Diana" last="Brainard">Diana Brainard</name><affiliation wicri:level="2"><nlm:affiliation>Gilead Sciences, Foster City, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gilead Sciences, Foster City, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Mchutchison, John G" sort="Mchutchison, John G" uniqKey="Mchutchison J" first="John G" last="Mchutchison">John G. Mchutchison</name><affiliation wicri:level="2"><nlm:affiliation>Gilead Sciences, Foster City, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gilead Sciences, Foster City, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Dufour, Jean Francois" sort="Dufour, Jean Francois" uniqKey="Dufour J" first="Jean-François" last="Dufour">Jean-François Dufour</name><affiliation wicri:level="4"><nlm:affiliation>Department of Hepatology, University of Bern, Bern, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Hepatology, University of Bern, Bern</wicri:regionArea><placeName><settlement type="city">Berne</settlement><region type="région" nuts="3">Canton de Berne</region><settlement type="city">Berne</settlement></placeName><orgName type="university">Université de Berne</orgName></affiliation></author><author><name sortKey="Van Vlierberghe, Hans" sort="Van Vlierberghe, Hans" uniqKey="Van Vlierberghe H" first="Hans" last="Van Vlierberghe">Hans Van Vlierberghe</name><affiliation wicri:level="1"><nlm:affiliation>Ghent University Hospital, Ghent, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Ghent University Hospital, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Van Hoek, Bart" sort="Van Hoek, Bart" uniqKey="Van Hoek B" first="Bart" last="Van Hoek">Bart Van Hoek</name><affiliation wicri:level="3"><nlm:affiliation>Department of Gastroenterology and Hepatology, Leiden University Medical Centre, Leiden, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Gastroenterology and Hepatology, Leiden University Medical Centre, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Forns, Xavier" sort="Forns, Xavier" uniqKey="Forns X" first="Xavier" last="Forns">Xavier Forns</name><affiliation wicri:level="3"><nlm:affiliation>Liver Unit, Hospital Clinic, CIBEREHD, IDIBAPS, University of Barcelona, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Liver Unit, Hospital Clinic, CIBEREHD, IDIBAPS, University of Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author></analytic><series><title level="j">The Lancet. Infectious diseases</title><idno type="eISSN">1474-4457</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiviral Agents (therapeutic use)</term><term>Benzimidazoles (therapeutic use)</term><term>Drug Therapy, Combination</term><term>Female</term><term>Fluorenes (therapeutic use)</term><term>Genotype</term><term>Global Health</term><term>Hepacivirus (classification)</term><term>Hepacivirus (drug effects)</term><term>Hepacivirus (genetics)</term><term>Hepatitis C, Chronic (complications)</term><term>Hepatitis C, Chronic (drug therapy)</term><term>Hepatitis C, Chronic (mortality)</term><term>Humans</term><term>Liver Cirrhosis (drug therapy)</term><term>Liver Cirrhosis (mortality)</term><term>Liver Cirrhosis (virology)</term><term>Male</term><term>Middle Aged</term><term>RNA, Viral</term><term>Ribavirin (therapeutic use)</term><term>Time Factors</term><term>Treatment Outcome</term><term>Uridine Monophosphate (analogs & derivatives)</term><term>Uridine Monophosphate (therapeutic use)</term><term>Viral Load</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral</term><term>Adulte d'âge moyen</term><term>Antiviraux (usage thérapeutique)</term><term>Association de médicaments</term><term>Benzimidazoles (usage thérapeutique)</term><term>Charge virale</term><term>Cirrhose du foie (mortalité)</term><term>Cirrhose du foie (traitement médicamenteux)</term><term>Cirrhose du foie (virologie)</term><term>Facteurs temps</term><term>Femelle</term><term>Fluorènes (usage thérapeutique)</term><term>Génotype</term><term>Hepacivirus ()</term><term>Hepacivirus (génétique)</term><term>Humains</term><term>Hépatite C chronique ()</term><term>Hépatite C chronique (mortalité)</term><term>Hépatite C chronique (traitement médicamenteux)</term><term>Mâle</term><term>Ribavirine (usage thérapeutique)</term><term>Résultat thérapeutique</term><term>Santé mondiale</term><term>Uridine monophosphate (analogues et dérivés)</term><term>Uridine monophosphate (usage thérapeutique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Uridine Monophosphate</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term><term>Benzimidazoles</term><term>Fluorenes</term><term>Ribavirin</term><term>Uridine Monophosphate</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Uridine monophosphate</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Hepacivirus</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Hepatitis C, Chronic</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Hepacivirus</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Hepatitis C, Chronic</term><term>Liver Cirrhosis</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Hepacivirus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Hepacivirus</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Hepatitis C, Chronic</term><term>Liver Cirrhosis</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Cirrhose du foie</term><term>Hépatite C chronique</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Cirrhose du foie</term><term>Hépatite C chronique</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term><term>Benzimidazoles</term><term>Fluorènes</term><term>Ribavirine</term><term>Uridine monophosphate</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Cirrhose du foie</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Liver Cirrhosis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Drug Therapy, Combination</term><term>Female</term><term>Genotype</term><term>Global Health</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>RNA, Viral</term><term>Time Factors</term><term>Treatment Outcome</term><term>Viral Load</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>ARN viral</term><term>Adulte d'âge moyen</term><term>Association de médicaments</term><term>Charge virale</term><term>Facteurs temps</term><term>Femelle</term><term>Génotype</term><term>Hepacivirus</term><term>Humains</term><term>Hépatite C chronique</term><term>Mâle</term><term>Résultat thérapeutique</term><term>Santé mondiale</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Treatment options are limited for patients infected by hepatitis C virus (HCV) with advanced liver disease. We assessed the safety and efficacy of ledipasvir, sofosbuvir, and ribavirin in patients with HCV genotype 1 or 4 and advanced liver disease.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Autriche</li><li>Belgique</li><li>Canada</li><li>Espagne</li><li>France</li><li>Italie</li><li>Nouvelle-Zélande</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suisse</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Californie</li><li>Canton de Berne</li><li>Canton de Zurich</li><li>Catalogne</li><li>Communauté de Madrid</li><li>Grand Londres</li><li>Hollande-Méridionale</li><li>Lombardie</li><li>Midlands de l'Ouest</li><li>Nouvelle-Galles du Sud</li><li>Piémont</li><li>Vienne (Autriche)</li></region><settlement><li>Barcelone</li><li>Berne</li><li>Birmingham</li><li>Leyde</li><li>Londres</li><li>Madrid</li><li>Milan</li><li>Sydney</li><li>Turin</li><li>Vienne (Autriche)</li><li>Zurich</li></settlement><orgName><li>Université de Berne</li><li>Université de Sydney</li></orgName></list><tree><country name="Allemagne"><noRegion><name sortKey="Manns, Michael" sort="Manns, Michael" uniqKey="Manns M" first="Michael" last="Manns">Michael Manns</name></noRegion></country><country name="France"><noRegion><name sortKey="Samuel, Didier" sort="Samuel, Didier" uniqKey="Samuel D" first="Didier" last="Samuel">Didier Samuel</name></noRegion></country><country name="Nouvelle-Zélande"><noRegion><name sortKey="Gane, Edward J" sort="Gane, Edward J" uniqKey="Gane E" first="Edward J" last="Gane">Edward J. Gane</name></noRegion></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Mutimer, David" sort="Mutimer, David" uniqKey="Mutimer D" first="David" last="Mutimer">David Mutimer</name></region><name sortKey="Agarwal, Kosh" sort="Agarwal, Kosh" uniqKey="Agarwal K" first="Kosh" last="Agarwal">Kosh Agarwal</name></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Mccaughan, Geoff" sort="Mccaughan, Geoff" uniqKey="Mccaughan G" first="Geoff" last="Mccaughan">Geoff Mccaughan</name></region><name sortKey="Angus, Peter" sort="Angus, Peter" uniqKey="Angus P" first="Peter" last="Angus">Peter Angus</name></country><country name="Espagne"><region name="Catalogne"><name sortKey="Buti, Maria" sort="Buti, Maria" uniqKey="Buti M" first="Maria" last="Buti">Maria Buti</name></region><name sortKey="Calleja, Jose Luis" sort="Calleja, Jose Luis" uniqKey="Calleja J" first="José Luis" last="Calleja">José Luis Calleja</name><name sortKey="Forns, Xavier" sort="Forns, Xavier" uniqKey="Forns X" first="Xavier" last="Forns">Xavier Forns</name><name sortKey="Prieto, Martin" sort="Prieto, Martin" uniqKey="Prieto M" first="Martín" last="Prieto">Martín Prieto</name></country><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Peck Radosavljevic, Markus" sort="Peck Radosavljevic, Markus" uniqKey="Peck Radosavljevic M" first="Markus" last="Peck-Radosavljevic">Markus Peck-Radosavljevic</name></region></country><country name="Suisse"><region name="Canton de Zurich"><name sortKey="Mullhaupt, Beat" sort="Mullhaupt, Beat" uniqKey="Mullhaupt B" first="Beat" last="Müllhaupt">Beat Müllhaupt</name></region><name sortKey="Dufour, Jean Francois" sort="Dufour, Jean Francois" uniqKey="Dufour J" first="Jean-François" last="Dufour">Jean-François Dufour</name></country><country name="Canada"><noRegion><name sortKey="Yoshida, Eric M" sort="Yoshida, Eric M" uniqKey="Yoshida E" first="Eric M" last="Yoshida">Eric M. Yoshida</name></noRegion></country><country name="Italie"><region name="Lombardie"><name sortKey="Colombo, Massimo" sort="Colombo, Massimo" uniqKey="Colombo M" first="Massimo" last="Colombo">Massimo Colombo</name></region><name sortKey="Rizzetto, Mario" sort="Rizzetto, Mario" uniqKey="Rizzetto M" first="Mario" last="Rizzetto">Mario Rizzetto</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Dvory Sobol, Hadas" sort="Dvory Sobol, Hadas" uniqKey="Dvory Sobol H" first="Hadas" last="Dvory-Sobol">Hadas Dvory-Sobol</name></region><name sortKey="Arterburn, Sarah" sort="Arterburn, Sarah" uniqKey="Arterburn S" first="Sarah" last="Arterburn">Sarah Arterburn</name><name sortKey="Brainard, Diana" sort="Brainard, Diana" uniqKey="Brainard D" first="Diana" last="Brainard">Diana Brainard</name><name sortKey="Denning, Jill" sort="Denning, Jill" uniqKey="Denning J" first="Jill" last="Denning">Jill Denning</name><name sortKey="Mchutchison, John G" sort="Mchutchison, John G" uniqKey="Mchutchison J" first="John G" last="Mchutchison">John G. Mchutchison</name><name sortKey="Pang, Phillip S" sort="Pang, Phillip S" uniqKey="Pang P" first="Phillip S" last="Pang">Phillip S. Pang</name></country><country name="Belgique"><noRegion><name sortKey="Van Vlierberghe, Hans" sort="Van Vlierberghe, Hans" uniqKey="Van Vlierberghe H" first="Hans" last="Van Vlierberghe">Hans Van Vlierberghe</name></noRegion></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Van Hoek, Bart" sort="Van Hoek, Bart" uniqKey="Van Hoek B" first="Bart" last="Van Hoek">Bart Van Hoek</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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